Abstract:
The work undertaken through this thesis responds to the problematic of proposing new access routes in the context of multi-component reactions, to a wide variety of heterocyclic molecules, highly functionalized and biologically active. The first chapter concerns the study of the effects of three catalysts on the synthesis of two major reactions. The study of the catalytic power of trisodium citrate in the preparation of pyrano[2,3-c]pyrazoles and the catalytic potential of potassium carbonate and pyridinium p-toluènesulfonate in the preparation of 4-arylmethylideneisoxazol-5(4H)-ones. Some of 4-arylmethylidene-isoxazol-5(4H)-one derivatives have been valued by an evaluation of their antibacterial and antioxidant activities. The second chapter aims in a first part to the development of a new pathway to arylhydrazones, in addition to the antibacterial and antioxidant biological evaluation of certain synthesized original derivatives. In the second part, the synthesis of a series of 4,5,6,7-tetrahydro-1H-indazoles and a series of pyrazole activated by a Lewis acid is further illustrated, besides the evaluation of the antioxidant and inhibitory activity of the alpha glucosidase enzyme of certain synthesized derivatives.
