DSpace Repository

Nouvelles procédures de préparation Des 4-ArylméthylidèneIsoxazol-5(4H)-ones et Pyrano[2,3-c]pyrazoles et nouvelle méthode de synthèse des Tétrahydro-1H-indazoles et Pyrazoles.

Show simple item record

dc.contributor.author Laroum, Rima
dc.contributor.author Debache, Abdelmadjid
dc.contributor.author Carboni, Bertrand
dc.date.accessioned 2022-05-25T08:26:24Z
dc.date.available 2022-05-25T08:26:24Z
dc.date.issued 2019-10-28
dc.identifier.uri http://depot.umc.edu.dz/handle/123456789/8210
dc.description.abstract The work undertaken through this thesis responds to the problematic of proposing new access routes in the context of multi-component reactions, to a wide variety of heterocyclic molecules, highly functionalized and biologically active. The first chapter concerns the study of the effects of three catalysts on the synthesis of two major reactions. The study of the catalytic power of trisodium citrate in the preparation of pyrano[2,3-c]pyrazoles and the catalytic potential of potassium carbonate and pyridinium p-toluènesulfonate in the preparation of 4-arylmethylideneisoxazol-5(4H)-ones. Some of 4-arylmethylidene-isoxazol-5(4H)-one derivatives have been valued by an evaluation of their antibacterial and antioxidant activities. The second chapter aims in a first part to the development of a new pathway to arylhydrazones, in addition to the antibacterial and antioxidant biological evaluation of certain synthesized original derivatives. In the second part, the synthesis of a series of 4,5,6,7-tetrahydro-1H-indazoles and a series of pyrazole activated by a Lewis acid is further illustrated, besides the evaluation of the antioxidant and inhibitory activity of the alpha glucosidase enzyme of certain synthesized derivatives.
dc.language.iso fr
dc.publisher Université Frères Mentouri - Constantine 1
dc.subject Chimie: chimie organique
dc.subject Réaction à composants multiples
dc.subject pyrano[2,3-c]pyrazoles
dc.subject 4-arylméthylidène-isoxazol-5(4H)-ones
dc.subject citrate trisodique;carbonate de potassium
dc.subject pyridinium p-toluènesulfonate
dc.subject arylhydrazone
dc.subject 4,5,6,7-tétrahydro-1H-indazole
dc.subject pyrazole
dc.subject activité biologique
dc.subject Multicomponent reaction
dc.subject trisodium citrate
dc.subject potassium carbonate
dc.subject p-toluenesulfonic pyridinium
dc.subject 4,5,6,7-tetrahydro-1H-indazole
dc.subject biological activity
dc.title Nouvelles procédures de préparation Des 4-ArylméthylidèneIsoxazol-5(4H)-ones et Pyrano[2,3-c]pyrazoles et nouvelle méthode de synthèse des Tétrahydro-1H-indazoles et Pyrazoles.
dc.type Thesis


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Browse

My Account