Abstract:
This work deals with phytochemistry and biological study of aerial parts of two species
belonging to the Apiaceae family: Athamanta sicula L. and Ferula longipes Coss.
Extraction, separation and purification by chromatographical methods of Athamanta sicula L.
led to the isolation of eight compounds. Similary this procedure yield to eleven compounds
from Ferula longipes Coss., one of which has a new structure. These compounds were
identified by the combination of spectroscopic methods including: UV-visible absorption
spectroscopy, high resolution mass spectrometry, RMN 1D and 2D, as well as comparison
with literature data.
The pure compounds and the ethyl acetate fraction of F. longipes Coss. showed an excellent
antioxidant activity compared to the standards. The petroleum and butanolic fractions of the
species Athamanta sicula L. showed a moderate anticholinesterase activity against AChE. The
pure compounds of the species Athamanta sicula L. showed a moderate cytotoxic activity.
