Abstract:
The present work concerns the phytochemical and biological studies of areal parts of
two Algerian plants belonging to the Asteraceae family: Cotula anthemoides L. and Pentzia
monodiana Maire. This study led to the isolation and identification of fifteen compounds of
Cotula anthemoides and eight compounds of Pentzia monodiana including five phenolic
acids, nine flavonoids from which one is new, three lignans, one sesquiterpene lactone, two
glycosyl phenolics, a glycosyl acid, a diterpene and an nucleoside. The structural
determination of the isolated compounds was established by the use of 1D and 2D NMR
spectroscopic techniques (1H, 13C, COSY, HSQC, HMBC and ROESY), by mass
spectrometry (ESI-MS and HRESI-MS) and by comparison with the literature data.
The evaluation of the antioxidant activity by 4 methods (DPPH, ABTS, CUPRAC and
chelating by ferrous ions) of the various extracts, showed a good activity of extracts from P.
monodiana compared to those of C. anthemoides. Furthermore, extracts of C. anthemoides
showed an interesting anticholinesterase activity. However, both of lignanes, flavonol and
flavones substituted in C-3, exhibited better antityrosinase and antiradical activities than some
flavones only.
