Abstract:
The phytochemical study of three species: Calendula stellata, Scabiosa stellata and
Salvia barrelieri led to the isolation of 55 compounds, from which 16 were new, by the use of
different chromatographic methods of separation and purification on solid or liquid support.
The isolated compounds were distributed through 27 saponosids, 7 triterpenes, 11 flavonoids,
7 iridoids and 2 chlorogenic acid derivatives. Two mono-iridoids and two flavonoids showed
an important antiradical activity (IC50:7-16 µM). Fourteen compounds exhibited a good
antibacterial activity (MIC: 15- 125 µg/mL). The new compounds showed a low to moderate
cytotoxic activity against all tested cell lines, except for the monodesmoside, obtained from
Scabiosa stellata (Scabiostellatoside F) which exhibited a good antiproliferative effect against
HT1080 (IC50 = 12 µM).
