Abstract:
In this manuscript we interested in the development of reactions with multicomponent
producing novel molecules through studying the efficiency of new catalysts.
This thesis consists of two main parts:
The first part has been devoted to the study of the Petasis reaction of and its
applications to the synthesis of novel structures which could exhibit interesting biological
properties. The first application of the Petasis reaction was the preparation of the novel 2-
hydroxy-1,4-benzoxazine derivatives, developing a novel method of synthesis by using an
ionic complex which was PPTS as a catalyst.
For the second application of the Petasis reaction, a series of novel α-arylglycine
derivatives was prepared.
In the second part of this work, two new rapid methods have been developed for the
synthesis of organophosphorus derivatives via multicomponent reactions. The first developed
method was the nanocatalyzed synthesis which has been used for the preparation of (2-amino-
3-cyano-4H-chromen-4-yl) phosphonates derivatives.
The second method was microwave-assisted synthesis which has been employed for the
preparation of novel pyrazolylphosphonate derivatives. These molecules which are bearing
pyrazole skeletons could possess wide variety of pharmacological properties.
