Abstract:
Our work is divised into two parts: phytochemical part and organic synthesis part.
In the phytochemical part we studied the Anti-bacterial and analgesic activities of
Tetraclinis articulata species of Cupressaceae family; the results of the antibacterial screening
showed that the butanol extract of the species studied has activity against Staphylococcus
aureus ATCC 25923 (Gram +) and Escherichia coli ATCC 25922 (gram -), the test on the
analgesic activity has proved that 'butanol extract of the same species has an important
percentage of inhibition of pain.
In the synthesis part, using the Buchwald-Hartwig mechanism 10 products was
synthesized saccharides Coupling products with peptides, six products obtained derivatives of
phenylalanine, and 4 products obtained from cysteine derivatives.
The scientific value of this last part is the development of a new method to couple
chemoselectively the function –SH of thiosugar with peptides, in presence of acid functions
acid functions and amino function of NHBoc amino acid without altering (epimerize) the
asymmetric carbon in position α of the acid and this in an ambient temperature and low time
(green chemistry).
