Abstract:
This manuscript encloses three principal parts: the first part, we have described the
synthesis of tetrazoles which are a class of heterocycles with a wide range of applications in
medicinal chemistry and in material sciences. We report herein a novel efficient process for
transforming a wide variety of nitriles into the corresponding tetrazoles in high yield, using a
simple and safe protocol.
We have reported in the second part, the protection of tetrazoles using pivaloyl chloride, the
same reaction is made to protect a wide range of alcohols with trityl chloride giving trityl
ethers and pivaloyl tetrazoles in good yields.
Finally, we have reported the use of lithium and a catalytic amount of naphthalene to remove
the pivaloyl protecting group from tetrazoles under very mild condition we have reported
successfully the use of a new catalyst for the detritylation of trityl ethers using indium and
lithium chloride generally with very good yields.
