Résumé:
"In this work, We developed a new method of the synthesis of sulfonic
calix[8]arenes derivatives.
We realized four substitution reactions of eight hydroxyl groups of
5,11,17,23,29,35,41,47-octa-tert-butyl-49,50,51,52,53,54,55,56-octakis calix[8]arene
and 49,50,51,52,53,54,55,56-octakis-calix[8]arene by 1,3-trimethylene and 1,4-
tetramethylene groups, leading respectively to the following four new sulfonic
calix[8]arenes :
• 5,11,17,23,29,35,41,47-octa-tert-butyl-49,50,51,52,53,54,55,56-octakis-
(3-propylsulphonic acid) calix[8]arene.
• 49,50,51,52,53,54,55,56-octakis-(3-propylsulphonic acid) calix[8]arene.
• 5,11,17,23,29,35,41,47-octa-tert-butyl-49,50,51,52,53,54,55,56-octakis-
(4-butylsulphonic acid) calix[8]arene.
• 49,50,51,52,53,54,55,56-octakis-(4-butylsulphonic acid) calix[8]arene).
The anticorrosive activity of the synthesized calix[8]arenes was studied by the
use of the three classical methods (gravimetric, potentiodynamic and impedance).
They showed an excellent inhibition of steel corrosion in HCl 1M.
The increase of the temperature decreases the inhibitory efficiency and the
calixarenes were adsorbed to the surface of steel according to isotherm model of
Langmuir, via a chemical adsorption.
The synthesized calixarenes showed an excellent in vivo and in vitro
anticoagulant activity, especially the derivative 5,11,17,23,29,35,41,47-octa-tertbutyl-
49,50,51,52,53,54,55,56-octakis-(4-butylsulphonic acid) calix[8]arene.
The POM (Petra, Osiris, Molinspiration) theory application on the synthesized
calixarenes showed that they are not toxic and that they are efficient as well as the
clinical coagulation inhibitors."
