Abstract:
This research investigates the dexamethasone
effect on some biochemical parameters, on
neutrophil/lymphocytes ratio (PN/L) in healthy horses, and on the numbe
r of PN in horses with chronic
obstructive pulmonary disease. It focuses also on the effect of methylprednisolone on
serum iron
concentration in healthy dogs.
Serum iron concentration increased significantly on days two and three and serum triglyceride
co
ncentration enhanced on days one and two after a single dose of dexamethasone (0,048mg/kg,
IV).
PN/L ratio increased 24 hours later.
As for the horses given dexamethasone (0,055mg/kg, IV SID) for four days, the serum iron
concentration decreased on days
one and two, whereas the serum triglyceride concentration increased
on days three and seven.
However, the other biochemical parameters did not change in the two experiments.
As for dogs, the methylprednisolone given orally at immunosuppressive dose (2mg
/kg BID) for seven
consecutive days caused a significant increase during the experiment.
Finally, the number of neutrophils was unaffected after treating horses affected with chronic obstructive
pulmonary disease.
