Résumé:
n view of medicinal importance of pomegranate grown locally in eastern of Algeria,
The current study was based on the valorization of Punica granatum L. peel hydroalcoholic
extract, by the determination of its acute toxicity and an evaluation of its analgesic activity by
in vivo approach in rats using acetic acid, hot plate and tail immersion methods, the extract
was used at the doses of 0.75, 1.50 and 3.00 g/kg while acetylsalicylic acid was used as a
standard reference drug (0.10 g/kg). In the acetic acid-induced model, the plant extract and
the reference drug significantly (p˂0.0001) reduced the abdominal writhing in rats when
compared to the control group, by increasing the percentage inhibition of writhing in a dose
dependent manner. In the hot plate and tail immersion models, the extract like the acetyl
salicylic acid showed high analgesic activity in a dose dependent manner and significantly
(p˂0.0001) increasing the pain reaction time. These results suggest significant analgesic
potential of Punica granatum L. peel extract which may act through both peripheral and central
mechanisms; probably due to the ability of its phyto-constituents to induce mechanisms of anti inflammatory effects
