Abstract:
Encapsulation of hydrophobic porphyrin derivative as photosensitizers (PS) into different forms of
nanoparticles (NP) is of a concern in this study for drug delivery and targeting in cancer
photodynamic therapy (PDT) applications.New formulations have been developed in this work for
the sustained release of the active agent by increasing the solubility. Entrapment of the PS in
anionic cyclodextrin (CD) structure was our first alternative. The resulting complex is then included
in chitosan (CS) and hydroxyapatite (HAP) nanoparticles according to ionotropic gelation method
in the presence of a crosslinking agent and biomimetic media. UV-Vis, FTIR spectroscopies, X-ray
diffraction (XRD) and SEM (scanning electron microscopy) are, among others, the methods used to
characterize the prepared systems.
The UV-Vis and FTIR results showed that the concentration of CD may play a significant effect on
the complexation phenomenon and morphology of each NPs. Indeed, the solubility of PS from CD
structure was found to be very significant. Both, the hybrid CS NPs and HAP NPs containing the
PS-CD active factor were able to be prepared in spherical form (300- 900 nm and 400- 956 nm
respectively) which provide a good interest for drug delivery in PDT technique
