Nouvelles ortho hydroxy bases de Schiff

Abstract

Seven Schiff bases were synthesized and characterized by hysicochemical methods. The imines were prepared by the condensation of the amines: 2-aminiphenol, 2-amino-4- chlorophenol, 2-amino-4-tert-butylphenol and 3'-aminoacetophenone with the various substituted aromatic aldehydes. The imines synthesized were characterized by UV-visible, FT-IR and as well as by the diffraction of the X-rays. The Schiff bases L1, L2, L4 and L7, were screened for their antimicrobial activities against the following species: Escherichia coli, Salmonella typhimurium, Staphylococcus aureus and Proteus mirabilis. All the results obtained show that these products have an influence on the different bacteria, and have no effect on the proteus. A comparative study of minimum inhibitory concentration (MIC) values of the Schiff base indicates that the compound (L1) exhibit higher antibacterial activity than the other ligands.