Synthèse en série hétérocyclique

Abstract

This manuscript encloses two principal parts: we have described the use of new basic catalysts for the multi-component reaction of Hantzsch type and Biginelli respectively. In the first chapter, includes the synthesis of 2-chloro-3-formylquinoline derivatives by subjecting by the corresponding acetanilides to Vilsmeier reagent (POCl3 /DMF)according to the method reported by O. Meth-Cohn and Coll. We have prepared six derivatives of 2-chloro-3-formylquinoléine. In the part, we have described the synthesis of 3,4-dihydropyrimidine quinolines following to the reaction of three components of Biginelli. These original dérivatives were obtained by a reaction of the 2-chloro-3-formylquinolines with ethyl acetoacetate, urea, and triphenylamine, as catalyst. The second chapter part we have reported successfully the use of a new catalyst for the Hantzsch cyclocondensation reaction. It's about nitrate strontium(II) and nitrate cadmium(II), which have been employed with catalytic amounts to reach the corresponding derivatives with generally very good yields. Yields are goods and all the products exhibited satisfactory spectroscopic analysis (RMN 1 H, RMN 13 C,IR).