Gènes de prédisposition au cancer prostatique.

Abstract

Prostate cancer is currently the most frequently diagnosed cancer and is the leading cause of death in men. In this sense, the objective of our work was to identify, through two statistical studies, some risk factors and histopathological parameters, as well as the possible involvement of genes encoding detoxification enzymes (CYP1A1, GSTM1 and GSTT1) and gene encoding a factor of angiogenesis (-2587C/A of VEGF) and the occurrence of prostate cancer after molecular analysis using the PCR/RFLP technique and multiplex PCR. The statistical study demonstrated an increase in the rate of prostate cancer from the age 60 years old with means age of 71.66±7.99. On the other hand, the presence of family history, smoking and occupational exposure (truck driver, builder, painter, farmer….) are recorded as risk factors implicated in this cancer. Also the sporadic form is the most common form in prostates cancers. Furthermore, the most prostate cancer are adenocarcinoma at the prostatic capsule (PSA >10 ng/ml ; Gleason Score8 ≤ GS ≤ 10). Finally, the genetic analysis of patients and controls for the studied genes presented by the pvalue indicates that no association between the deletion of GSTM1 and the CYP1A1 3801T>C variant and prostate carcinogenesis. However, the deletion of GSTT1 and the double deletion of GSTM1/GSTT1 are involved in the development of prostate cancer. Thus the results of the VEGF-2578C/A variant show a significant difference with susceptibility to prostate cancer.