Étude génétique des gliomes

Abstract

Gliomas are the most common primary intraparenchymal tumors of the central nervous system with a very poor prognosis. Glioblastoma accounts for the majority of gliomas (56,6%). Relative survival estimates for glioblastoma are quite low; 5.6% of patients survived five years post diagnosis. Several evidences demonstrate the importance role of genetic factors in glioma development. The evolution of cytogenetic and molecular biology researches, has largely elucidated the molecular mechanisms of gliomagenesis, which have a lot of impact in diagnosis, prognosis, and therapeutic to predict responses to different therapies proposed. Our case-control study will focus on two genetic polymorphisms: The C677T polymorphism of MTHFR and the I / D polymorphism of ACE on blood sample. The results obtained was:  the genotype TT of C677T MTHFR polymorphim is highly associated with high genesis of glioma in East-Algerian population. The presence of T allele may contribute to development of glioma in this population.  the DD genotype of I/D ACE polymorphism in associated with high risk to develop glioma in our population. These results allow us to propose the study of these genes for therapeutic (use of ACE inhibitors and folate substitution) and deserve confirmation by the realization of other studies involving a larger sample of glioma patients.