Evaluation du potentiel pharmacologique et hépatotoxique du Teucrium polium L.

Abstract

Teucrium polium L. is a medicinal plant widely used in Algeria to treat a variety of human pathology. An ethnobotanical survey was conducted during the period from June 2011 to December 2012, among 269 people who use medicinal plants (villagers and herbalists) through 18 willayas in eastern Algeria on the traditional use of Teucrium polium L and ethnobotanical indices were calculated. The results of the ethnobotanical survey revealed the importance of the practice of phytotherapy by the population of the investigated region and helped to contribute to the transformation of popular knowledge from oral to written through the establishment of the monograph of Teucrium polium L. Moreover dosage and dosage seems to be very poorly controlled by our traditional healers which could be dangerous for the health of consumers. The evaluation of the acute toxicity of the aqueous extract of Teucrium polium L. after 14 days of treatment in rats was carried out and the value of the LD50 was estimated by two methods of calculation. The acute toxicological study estimated the LD 50 of this plant to more than 3000 mg / kg which places it in the class 4 of toxicity therefore ""slightly toxic"". In the subchronic oral toxicity study, administration of 800 mg / kg, 1600 mg / kg and 2500 mg / kg / day of the aqueous extract demonstrated that it acts negatively on the growth of the treated and treated rats. disrupts some hematological and biochemical parameters related to liver function (transaminases), renal in the different lots treated. The histological observation of the organs was characterized by the presence of structural alterations of the liver and kidney with significant differences (𝑃> 0.05)