Synthèse, caractérisation et propriétés de nouveaux composés organostanniques.

Abstract

1,10-phenanthroline and its derivatives are widely used in chemistry and biology, these molecules are useful in a range of biological (anti-Alzheimer, antifungal, anticancer,...) and chemical processes. Tin (IV) complexes have been extensively studied for their biological and therapeutic effects, including anticancer, antibacterial, antifungal and antiviral features. The aim of this work is to synthesize Phen-derived complexes and their biological studies. In this thesis, we contribute eight organotin compounds, two with the ligand 1,10- Phenanthroline, three with the ligand 1,10-Phenanthroline-5,6-diamine and its derivatives, and three with 1,10-Phenanthroline-5,6-dione and its derivative. These complexes have shown promising results in anti-cholinesterase, antioxidant and antifungal activities, confirmed by Docking and DFT density functional theory