Synthèse, caractérisation structurale et activité biologique des complexes de coordination à base de Sulfaméthoxazole.

Abstract

During this research work carried out at the Environmental and Structural Molecular Chemistry Research Unit of the University Constantine 1, we have synthesized six new original compounds based on sulfamethoxazole ligand: four mononuclear complexes with zinc, copper and cobalt, also, two polymers based on cobalt and silver metals; The crystal structures of the latter were determined from low temperature x-ray diffraction data, they are characterized by preliminary analysis and by means of IR plus UV-Vis, accomplished by thermal analysis, studying hydrogen bond networks, also, Hirshfeld surface analysis and finalized by an entire calculation performed using the density functional theory DFT. The in-vitro antibacterial/antifungal activities of the free ligand (SMX) and its zinc and copper complexes were evaluated using the well- diffusion method in DMSO (dimethyl sulfoxide). Cotrimoxale is used as positive control to make meaningful comparison.