PARAMETRIC STUDY OF COATING BY COOLING CRYSTALLIZATION

Abstract

The purpose of this work, the parametric study of the operating conditions that can affect the new technology of coating of ibuprofen naked tablets manufactured by compression by surose solution using cooling crystallization. Seeding crystallization was used in this new process, tablets of ibuprofen were used as heterogeneous seeds (core materials) were coated with sucrose was used as coating material. The growth rate on the surface of the naked tablets and surface morphologies were investigated under various experimental conditions. These experimental conditions are: The viscosity of the coating solution, surface properties of the naked ibuprofen tablets (surface tension and contact angle). The optimal conditions were found to achieve compact and uniform coating