EXPERIMENTAL STUDY OF DRYING CONDITIONS EFFECT ON STARCH SINGLE DROPLET SHRINKAGE AND MORPHOLOGY DURING DRYING

Abstract

The product quality is an important issue in pharmaceutical industry. Spray drying process is an appropriate method to obtain dry powders with a controlled quality (size and morphology). In this paper, a single droplet drying suspension device is used for continuous monitoring of the drying process to investigate the shrinkage behavior of hydroxypropyl pea starch (HPS) solution droplet during drying. The understanding of shrinkage behavior of droplets, particle formation and knowledge of the drying conditions effect during drying is of great importance for quality control. HPS powder production by spray drying is widely used as pharmaceutical ingredient; however there are only a few fundamental studies investigating the droplet drying behavior including the shrinkage behavior and morphology. The objective of this study was to establish the prospects to determine the effect of operational conditions on droplet/particle morphology