http://depot.umc.edu.dz/handle/123456789/4833 2026-06-01T13:18:28Z http://depot.umc.edu.dz/handle/123456789/4866 Les anomalies des métabolismes lipidiques chez les diabétiques dans la wilaya de Bordj Bou Arreridj. Atallah S; Nouri Allaoua The Diabetes mellitus is a commun metabolic disorder affecting the metabolism of carbohydrates, lipids and proteins. In this study 93 diabetic patients were used and investigated according to the sex ,type of diabetes, the presence or absence of ketosis and duration of disease. According to our results, a male predominance among the type1 diabetes was noted against a female predominance at the type1 diabetes. Through an evaluation of the carbohydrate and lipid parameters has revealed to us a possible relationship between HbA1c, duration of diabetes and hyperlipidemia. Through the biochemical investigation of the carbohydrate and lipids parameters had revealed to us a possible relation ship between HbA1c,diabete duration and hyperlipidemia (A significant positive correlation with total cholesterol LDL- cholesterol and triglyceride and a significant negative correlation with HDLcholesterol). In type 1 diabetes, the mean of triglyceride and total cholesterol are usually normal ,or at the upper limit of normal. HDL- cholesterol is normal or slightly increased poorly. In Type 2 diabetics have most often high triglycerides and low HDLcholesterol levels however the LDL- cholesterol level is normal or slightly increased. Dyslipidemia are common mainly type 2 diabetic patient's care requires in addition to the improvement in glycemic control, elimination of other risk factors." 72 f. 2014-01-01T00:00:00Z http://depot.umc.edu.dz/handle/123456789/4865 Etude préliminaire d’une carence hydrique et alimentaire chez le rat; Effets physiologiques et endocrines Boudah Abedenacer; Khouni Fatiha The aim of our study was to evaluate the effect of water deprivation, food deprivation and their combination for three days on the metabolic and endocrine status in rats. The level of total lipids and triglycerides were significantly reduced, however the level of total cholesterol, HDL cholesterol and LDL cholesterol was increased in all groups. The results of urine tests (kaliuresis, natriuresis, proteinuria) showed a significant signs of dehydration with a significant increase in total protein in dehydrated rats. Thyroid failure reflected by a decrease in the level of plasma FT4 and FT3 was noted after dehydration, malnutrition and their association. A significant decrease in plasma TSH was observed in malnourished rats and dehydrated and malnourished rats; this level was decreased but not significantly in dehydrated rats. In our study, we showed that the water and food deprivation or altogether activate hepatic glycogenolysis, muscle lipid oxidation. On the other hand, it seems that nutritional stress modifies the pituitary-thyroid axis through mechanisms different from those of osmotic stress. 86 f. 2014-01-01T00:00:00Z http://depot.umc.edu.dz/handle/123456789/4864 Etude comparative de l’alloxane et de la streptozocine dans le diabète expérimental chez le rat blanc; Etude histologique du pancréas endocrine et la variation des paramètres sanguins Boudah Abedenacer; Bouhouche Ibtissem The streptozotocin and alloxan are the moste prominent diabetogenic chemical agents. The objective of the present work was undertaken to clarify the comparative effect of alloxan and streptozotocin on some biochemical parameters (glycemia, Insulin, total cholesterol, triglyceridemia , total proteins) and on histological structure of the endocrine pancreas in white rats with experimental diabetes during (2 - 3 days). The intraperitoneal injection of 250 mg / kg of alloxan causes after 24 h, hypoglycemia followed by a very high significant hyperglycemia (5 g / l), a significant hypertriglycerdemia hyperinsulinemia and hypercholesterolemia wasn’t significant. The treatment with a dose of 200 mg / kg of alloxan showed a hyperglycemia and hyperinsulinemia but not significant and the level of cholesterol was increased high significantly after 72h. While a dose of 150 mg / kg of alloxan caused ; after 72h, hyperglycemia and hyperinsulinemia, hypercholesterolemia but not significant. The results of treatment with STZ (60 mg / kg) showed a significant hyperglycemia after 24 h, hyperinsulinemia and hypercholesterolemia non significant however the other blood parameters (triglycerdemia, proteinemia) had a similar levels in contrast to control group. Histological sections of the endocrine pancreatic showed a large necrotic regions in rats treated with aloxane than those treated with stz. The results obtained in this study showed that the treatment with alloxan and stz causes stable symptomes of diabetes (polyphagia, polyuria, polydipsia, a fall in body weight, hyperglycemia) with different effects. 89 f. 2017-01-01T00:00:00Z http://depot.umc.edu.dz/handle/123456789/4863 "Effect of Algerian olive oil on cardiovascular diseases and lipids status in hyperhomocysteinemia treated mice" Zerizer S; Sakhri Fatima Zahra "L'huile d'olive est l’une des huiles végétales les plus anciens et le seul qui peut être consommé dans sa forme brute, sans traitement préalable. Les avantages bien connus d'huile d'olive pour la santé sont liées à sa composition en acides gras et en biomolécules mineur, tels que les vitamines et les antioxydants naturels. L'homocystéine (Hcy) est un acide aminé soufré synthétisée dans le corps par la conversion de la méthionine. Il existe un équilibre dans le métabolisme de l'Hcy dans les conditions physiologiques. En cas d’excès, l’hyperhomocystéinémie (HHcy), considéré comme un facteur de risque indépendant des maladies cardio-vasculaires. Dans cette étude, nous avons dosé l’Hcy plasmatique, les paramètres lipidiques (cholestérol total, LDL, HDL, triglycérides) et les enzymes antioxydants (glutathion réduit) chez des souris auxquelles nous avons administré (400mg/kg) de L-méthionine pendant 21 jours. Après administration orale de la dose élevée de L-méthionine, la dégradation de cette dernière produit un excès d’Hcy dans le plasma sanguin, qui est à son tour exerce une action angiotoxique sur l’aorte iliaque et abdominal et une action toxique sur le coeur et le foie. Ceci est montré à la perte et la dégénérescence de l'endothélium, la fenestration et la formation de cellules spumeuses dans les médias de l'aorte abdominale et iliaque, également l'altération du muscle cardiaque et la nécrose du foie. Cependant, l’histologie aortique des souris traitées par la L-méthionine avec huile d’olive (7ml/60kg) montre un endothélium intact et des cellules musculaires avec des noyaux fusiformes. Néanmoins, on a observé quelques noyaux ovales et quelques cellules spumeuses. Ainsi, le traitement par l’huile d’olive diminue le taux plasmatique d’Hcy, cholestérol total, triglycéride et LDL-c cependant les niveaux des HDL-c et le glutathion réduit augmentent. Donc, l’huile d’olive utilisé dans cette étude exerce un effet antioxydant. Les résultats obtenus dans cette étude montrent que l’huile d’olive Algérienne peut être considérer comme une source naturelle pour prévenir et traiter les maladies cardiovasculaires. Les mots" 89 f. 2017-01-01T00:00:00Z